Join Virscio at ARVO 2024: Enabling the next generation of innovation in Ophthalmology
Visit us at Booth #5121 to engage with our team of experts and learn how we are improving clinical outcomes through improved alignment of test systems to disease biology.
The ARVO Annual Meeting is the world's leading forum for eye and vision research, where scientific discoveries and innovations are shared and new collaborations and partnerships are born. We are looking forward to seeing many longtime friends and colleagues, and to establishing new connections with those that share our passion for innovation and clinical impact.
Planning in vivo study designs or programs that might benefit from a focused preclinical strategy or study design discussion? Schedule a time to meet with one of with one of our ophthalmology subject matter experts while at ARVO by clicking here. In addition, we always welcome spontaneous visits to our booth where you can learn more about Virscio, meet the team, and explore our unique preclinical and translational services and capabilities.
Posters and Presentations
Don’t Miss These Virscio Events at ARVO
Virscio is thrilled to be presenting some of the exciting science our team has advanced in the past year in posters highlighting our continued characterization and application of the green monkey as clinically relevant translational test system.
Resting Intraocular Pressure in African Green Monkeys and Cynomolgus Macaque
Presented by: Jeff Gidday
Poster Board Number: A0452
Date & Time: Tues., May 7, 8:30 a.m. to 10:15 a.m.
This study provides validated baseline intraocular pressure (IOP) values for African green monkeys, comparing them to the well-documented values of cynomolgus macaques. By documenting daily variations and responses to latanoprost, a common treatment for glaucoma, the research underscores the similarities and stability in IOP between the two species under sedation. This data is valuable for the preclinical safety assessment of pharmaceuticals, especially in understanding species-specific responses and in regulatory submissions.
An AI-driven workflow to improve macula detection and retinal ganglion cell quantification in preclinical nonhuman primate histopathology
Presented by: Golnaz Jalalahmadi
Poster Board Number: B0403
Date & Time: Tues., May 7, 1:15 p.m. to 3 p.m.
This poster outlines an innovative approach to enhance the detection and quantification of the macula and retinal ganglion cells (RGCs) in hematoxylin and eosin (H&E) stained whole slide images (WSI) of nonhuman primate tissues. Employing advanced AI techniques, the researchers aim to address the challenges associated with manual cell counting and subtle histopathological assessments in the foveal region of the retina, which can be prone to human error. The study serves as a proof of concept that not only boosts accuracy but also improves the efficiency of histopathological workflows, demonstrating significant potential for both research and clinical applications in diagnosing and evaluating retinal diseases like glaucoma.
Pressure- and time-dependent glaucomatous pathology in nonhuman primates with intraocular pressure elevation
Presented by: Matthew Lawrence
Poster Board Number: B0234
Date & Time: Tues., May 7, 3:30 p.m. to 5:15 p.m.
This research evaluates the long-term effects of elevated intraocular pressure (IOP) on the retina and optic nerve of African green monkeys, utilizing a trabecular laser model. The findings reveal critical insights into the progression of glaucomatous changes, such as retinal nerve fiber layer thinning and optic nerve head cupping. Furthermore, the study establishes a correlation between the rate of change in Bruch's membrane opening-minimum rim width (BMO-MRW) and applied pressure, providing a robust preclinical model for assessing the efficacy of neuroprotective therapies against glaucoma.
Quantitative assessment of light-induced retinal damage in African green monkey
Presented by: Cavit Agca
Poster Board Number: A0336
Date & Time: Wed., May 8, 10:30 a.m. to 12:15 p.m.
This poster introduces a model of light-induced retinal damage in African green monkeys, designed to mimic conditions like age-related macular degeneration (AMD) and retinitis pigmentosa (RP). The model utilizes controlled light exposure to induce synchronized photoreceptor cell death, allowing for a precise evaluation of retinal degeneration processes and the efficacy of potential neuroprotective treatments. This novel model aids in understanding the role of natural light exposure in degenerative retinal diseases and in developing therapeutic strategies.
Quantitation of dose-dependent DL-a-aminoadipic acid (DLAAA)-induced chronic retinal neovascularization and macular edema in nonhuman primates
Presented by: Bibiana Iglesias
Poster Board Number: B0200
Date & Time: Thurs., May 9, 11:45 a.m. to 1:30 p.m.
This study characterizes the dose-dependent effects of intravitreally injected DL-a-aminoadipic acid (DLAAA) in inducing pathological retinal vessel morphology and macular edema in St. Kitts African green monkeys. The research highlights how varying doses of DLAAA can simulate different severities of retinal degeneration and neovascularization, closely mirroring human retinal conditions. The findings are crucial for the development of translational preclinical models that can effectively test new treatments for retinal neovascular diseases.
Meet with us during the ARVO Annual Meeting
Discover how Virscio can meet your ophthalmological research needs!
Curious about our preclinical experience and capabilities? Have a specific study you need to conduct to advance your program and/or secure funding? We would be happy to meet with you to consult and define the most efficient path to clinical success.